Methylcobalamin vs Cyanocobalamin: What’s the Difference?

By Nicolas Martineau, B.Sc. Nutrition

Vitamin B12: An Essential Nutrient

B vitamins are essential for the proper functioning of the body. Among them, vitamin B12 holds a special place. It contributes to:

• the production of red blood cells,

• DNA synthesis,

• the healthy functioning of the nervous system.

Daily requirements vary slightly:

• Adults: 2.4 µg,

• Pregnant women: 2.6 µg,

• Breastfeeding women: 2.8 µg.

The daily amount is important, but so is the form of vitamin B12 consumed. Two common forms are cyanocobalamin and methylcobalamin. Both are effective, but they differ in terms of conversion, bioavailability, and impact on health.

Cyanocobalamin: The Most Common Form

Cyanocobalamin is the most widely used form of B12 in supplements and injections. Its advantages include:

• stability,

• low cost,

• easy availability.

However, it is not active in this form. Once ingested, it must be converted in the liver into active forms such as methylcobalamin and adenosylcobalamin.

👉 This conversion process can be slower in some people, especially those with:

• digestive disorders,

• reduced absorption,

• severe vitamin B12 deficiency.

Methylcobalamin: An Active Form of B12

Methylcobalamin is the active form of vitamin B12. It is ready to be used by the body immediately, without the need for conversion.

Its key roles include:

• contributing to the synthesis of myelin (the protective sheath around nerve fibers),

• supporting the production of methionine, an essential amino acid involved in detoxification and tissue repair.

👉 Because it is directly bioavailable, methylcobalamin is often considered more effective, particularly for people with absorption issues or neurological problems.

Bioavailability and Absorption

Bioavailability refers to the amount of vitamin B12 that is actually absorbed and used by the body.

• Some studies suggest that methylcobalamin may be better absorbed and utilized, especially in individuals with metabolic concerns.

• Cyanocobalamin, being more stable and cost-effective, is still widely used to correct deficiencies, particularly through intramuscular injections.

Methylcobalamin or Cyanocobalamin: Which Should You Choose?

The choice depends on your needs and overall health status.

• Cyanocobalamin: recommended for most people. It is effective, affordable, and widely used to treat deficiencies.
  👉 [See Land Art Vitamin B12 Cyanocobalamin]

• Methylcobalamin: preferable for people with absorption issues, metabolic disorders, or neurological conditions. It is directly active and well tolerated.
  👉 [See Land Art Vitamin B12 Methylcobalamin]

In Summary

Both forms of vitamin B12 are effective, but:

• Cyanocobalamin remains the most common and economical option.

• Methylcobalamin, being already active, may offer specific benefits, particularly for those with metabolic or neurological issues.

👉 The choice between methylcobalamin and cyanocobalamin should always be tailored to individual needs and ideally guided by a healthcare professional.

References:

https://www.nature.com/articles/ejcn2014165

https://www.researchgate.net/profile/Jeetendra-Gupta/publication/339412930_Potential_Benefits_of_Methylcobalamin_A_Review/links/5e4ff1bd458515072dafa8be/Potential-Benefits-of-Methylcobalamin-A-Review.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC8311243/#:~:text=The%20results%20revealed%20that%20cyancobalamin,%3D78.5%20pcg%2Fl).

https://www.canada.ca/fr/sante-canada/services/aliments-nutrition/saine-alimentation/apports-nutritionnels-reference/tableaux/valeurs-reference-relatives-vitamines.html